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In monkeys, the CRH1-receptor two studies of CSF concentrations, both of which found density is high in most amygdaloid nuclei, the cingulate abnormally increased in chronic, combat-related PTSD cortex, the PFC, the insular cortex, the parietal cortex, the 239,240. The CRH2-receptor density is high relative to control samples 241,242. Although these obser- in the cingulate cortex, the mPFC, the CE, the CA-1 region vations would appear most consistent with findings that of the hippocampus, and the PVN and supraoptic nucleus basal cortisol secretion and excretion are abnormally in- of the hypothalamus.
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